Introduction to bioinformatics
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Contents |
Goal
Bioinformatics is a scientific discipline that supports and advances biomedical research with management and (statistical) analysis of experimental data. Bioinformatics combines expertise and technologies from molecular biology, data analysis, database technology and information technology.
The course provides biomedical researchers with sufficient theoretical and practical skills to adequately apply bioinformatics in their own research. This course combines lectures with computer exercises and aims at introducing the participant in the basic principles underlying bioinformatics tools.
Registration Fill out the form at the AMC graduate school website Next course: 9-13 February 2009 Schedule 2009 (pdf)
Content
Several important topics are presented and put into practice during this course. A general introduction will explain the position and impact of bioinformatics in today’s biomedical research. An important topic covers the content and use of public biological databanks such as GenBank, which is an explosively growing database containing nucleotide sequences.
Sequence analysis is another important area in the bioinformatics and includes comparison of nucleotide or protein sequences via (multiple) sequence alignment, the identification of genes or other features in sequences or phylogenetic analysis to establish the evolutionary relationships between genes or organisms.
The DNA microarray technology is used to measure gene expression profiles on a genomewide scale. In this course the basic principles of image analysis and microrarray analysis are explained. Finally, the Human Genome Project and the results of this project are presented.
* Introduction bioinformatics
- Biological databases
- Bioinformatics of sequencing
- Sequence alignment and BLAST
- Scoring matrices
- Statistical analysis of transcript counts
- DNA microarray analysis
- Gene finding
- Networks
- Human genome project
- Phylogenetics
- SNPs and genetical genomics
Format
Several AMC professionals contribute to this course to demonstrate how state of the art bioinformatics is applied in biomedical research. The course runs one full week (36 hours) and is organized once a year. Scheduled is 9 - 13 February 2009.
Documents
- Schedule 2009 (pdf)
- Reviews next generation sequencing
- Teacher notes (available on request)
Lectures
- 2009 Introduction to Bioinformatics(pdf)- Antoine van Kampen
- 2009 Biological databases(pdf)- Antoine van Kampen
- Sequence alignment (pdf) - Barbera van Schaik
- BLAST (pdf) - Barbera van Schaik
- ScoringMatrices(pdf) - Antoine van Kampen
- Statistical analysis of transcript counts (pdf) - Jan Ruijter
- DNA microarray analysis (pdf) - Perry Moerland
- Gene Finding(pdf)- Antoine van Kampen
- Networks (pdf) - Miranda Stobbe
- Phylogenetics (pdf)- Antoine van Kampen
- SNPs and genetical genomics (pdf) - Perry Moerland
Other information
- Location: Academic Medical Center, Amsterdam.
- Date: 9-13 February 2009
- Language: English.
- Maximum number of participants: 20 (AMC and AMC Medical Research B.V. employees are given enrolment privilege).
- Certificate: In order to attain a certificate, course members must attend all lectures and workshops. All assignments must be carried out adequately. Attendance will be registered.
- Registration: AMC graduate school
- Costs: none
- More Information: email Barbera van Schaik or the AMC Graduate School
Course exercises
Programs used in this course are available on the PCs in L-005 via 'Start - Geneeskunde - Bio Informatica'.
